Peer-reviewed scientific journal publishing research on biotechnology, including genomics, drug development, and therapeutic engineering.
HitSV, a new structural-variant caller, posted genotype F1 scores 10% to 72% above existing callers on the HG002 benchmark. The same abstract reports a 31.5% larger 1KGP phase 4 callset, and HG002 F1 is the only accuracy figure it reports.
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Researchers report lipid nanoparticles that program mouse NK cells into CAR NK cells in vivo, reaching up to about 80% transfection. Regression in two humanized blood-cancer models is the nearest the abstract comes to human cells.
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Shift Bioscience reports in Nature Biotechnology that deep learning perturbation models often beat simple baselines once the metric can detect a biological signal. A model that looked no better than a baseline may just have been scored with a metric too blunt to tell.
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Trolle and colleagues screened millions of synthetic metabolic pathways at once and grew hamster cells without the essential amino acid valine. Their method, shotgun genetic engineering, breaks the slow build-and-test loop that had confined such work to fast-growing microbes.
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Researchers found 159 R2 retrotransposons in 1,139 avian genomes and engineered variants that reached up to 60% gene insertion in human primary cells. These are RNA-only tools, able to add a gene to the genome without delivering any DNA to the cell.
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MIT researchers used an AI algorithm to reformulate mRNA vaccine nanoparticles that stay stable for a year at room temperature and two months near 38C. In mice the shots matched a Moderna-like vaccine. The lab says the change could loosen the ultracold cold chain.
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The six clocks agreeing matters more than the years they report, because a drug that quiets an inflamed lung moves the same blood proteins whether or not it slows ageing anywhere else.
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Its authors say an 18-dimensional property grid, which decides which chemical subspaces get docked at all, cuts compute by orders of magnitude, and they back the platform with nanomolar inhibitors of two targets plus co-crystal structures.
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Enhanced rock weathering's problem has always been rate rather than chemistry, and a Nature Biotechnology result attacks the rate directly. The 2.6-fold gain was measured on kilograms of mineral in a flow reactor.
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A pilot bioreactor running on unprocessed seawater and acetate pulled 0.50 grams of CO2 a day out of the air from 4 kilograms of rock, a modest number obtained by direct measurement in a tank rather than by inference from a field plot.
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A Nature paper reports promoter and CRISPR toolsets that transfer across distantly related gut Clostridia, then uses them to toggle two host-relevant metabolites in mice. The methods stay paywalled.
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A University of Basel group has published Bonsai in Nature Biotechnology, replacing the two-dimensional map with a branching tree. The fidelity gains are asserted qualitatively, not quantified.
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The atlas turns kinase-inhibitor selection into a matching problem. What is missing is evidence that the match predicts which drug works in a patient.
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AIntibody tested 511 antibodies from 29 organizations on three tasks. Ranking clones inside HCDR3 clusters was worse than random for every model but one.
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A Nature Biotechnology paper reports a hybridization-driven synthesis method that builds over 1,000 distinct gene fragments in a single reaction, then uses it to find PETase variants beating the standard enzyme.
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A screen of 337 virus genomes found stabilizing elements; one, Pt1, pushed linear mRNA half-life from 7.6 to 23.1 hours by recruiting nuclear poly(A) polymerases in the cytoplasm.
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