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bioRxiv

bioRxiv is a free online repository for unpublished preprints in biology and life sciences, allowing researchers to share findings before peer review.

Known aliases

  • bioRxV

Current stories

productOne report1 publisher

Pig kidneys stored at -150 degrees C made urine after rewarming and transplant

Minnesota researchers rewarmed pig kidneys stored at -150 degrees C, one for over a year, and the transplanted organs made urine. The work is a bioRxiv preprint without peer review, and the team has yet to show the kidneys sustain life long term.

Reality

Evidence50
Adoption
Not scored
Hype gap+30
Incentives
Not scored
Confidence55
scienceOne report1 publisher

UCL preprint maps 2-micrometre channels that carried tau and amyloid toward the mouse brain surface

UCL researchers report a mesh of 2-micrometre channels that carried labelled tau and amyloid beta toward the brain surface in mice, in an unreviewed preprint. They are a candidate exit for the proteins that build up in Alzheimer's, so far untested in a living human brain.

Publishers:sciencealert.com

Reality

Evidence38
Adoption
Not scored
Hype gap+15
Incentives
Not scored
Confidence35
scienceOne report1 publisher

Freedivers' brain networks reorganize over seven months of breath-hold training

Julia Micaux's Paris-Saclay team tracked 17 freedivers through seven months of training and saw connectivity shift across five large-scale brain networks. The authors link the change to preserved memory, but their design can only show that the two go together.

Publishers:sciencealert.com

Reality

Evidence35
Adoption
Not scored
Hype gap+30
Incentives
Not scored
Confidence40
scienceConfirmed3 publishers

In mice and 11 patients, transplanted hearts moved toward their hosts' biological age

Jesse Poganik's Harvard group reports that donor hearts shifted toward their recipients' biological age in mice and in 11 human transplants. The bioRxiv preprint has not been peer reviewed, so it is enough to question the under-45 donor preference but not to rewrite it.

Perspective Coverage

3 publishers
Builder
Builder 45%
Operator
Operator 43%
Investor
Investor 12%

Reality

Evidence45
Adoption
Not scored
Hype gap+30
Incentives
Not scored
Confidence55
scienceOne report1 publisher

Preprint puts Jefferson at 99.96 percent likely to have fathered a son with Sally Hemings

A bioRxiv preprint puts Thomas Jefferson near 99.96 percent likely to have fathered at least one of Sally Hemings's sons, using DNA from locks of his preserved hair. A 1998 Y-chromosome test could point only to the Jefferson male line, and the analysis behind the new figure has not been peer-reviewed.

Reality

Evidence45
Adoption
Not scored
Hype gap+30
Incentives
Not scored
Confidence40
scienceOne report1 publisher

Plunderfish cells cultured for the first time show enlarged lysosomes at near-freezing

A Cambridge and British Antarctic Survey team grew spiny plunderfish cells in the lab, then imaged them alive near 0 degrees Celsius. The preprint reports enlarged lysosomes and more networked mitochondria than in a temperate fish.

Reality

Evidence42
Adoption
Not scored
Hype gap+30
Incentives58
Confidence57
scienceOne report1 publisher

Basecamp raises $140M to push model-designed recombinases toward in vivo cell therapy

The company says the money will train the next generation of its EDEN models. The published evidence so far is one January bioRxiv preprint, co-authored with Nvidia, whose venture arm also put money into the round.

Publishers:genengnews.com

Reality

Evidence35
Adoption30
Hype gap+38
Incentives80
Confidence45
investOne report1 publisher

Google DeepMind put 111 kilobytes of prediction behind each of 9 billion DNA variants

AlphaGenome Atlas scores every possible single-letter change in the human genome and hands the result to anyone with a browser, which moves the scarce input from computing a prediction to confirming one. Price and drug-developer partnerships go unmentioned in the release.

Publishers:prnewswire.com

Reality

Evidence42
Adoption20
Hype gap+28
Incentives72
Confidence55
scienceOne report1 publisher

BTI and Cornell pre-compute 800 million mass spectra to give unknown metabolites something to match

Rather than wait for experimental libraries to fill, the Cornell and BTI tool indexes a chemical space roughly a thousand times wider. What a query returns is a candidate structure rather than a confirmed one.

Publishers:phys.org

Reality

Evidence42
Adoption20
Hype gap+32
Incentives62
Confidence50
scienceOne report1 publisher

Finland sequenced a Saimaa ringed seal, and gave its managers a coordinate system for inbreeding

A team in Finland assembled the species' genome from a living seal caught during a translocation programme, and posted it as a preprint. The population's inbreeding numbers still have to be measured.

Publishers:phys.org

Reality

Evidence55
Adoption30
Hype gap+14
Incentives72
Confidence52