Pig kidneys stored at -150 degrees C made urine after rewarming and transplant
Minnesota researchers rewarmed pig kidneys stored at -150 degrees C, one for over a year, and the transplanted organs made urine. The work is a bioRxiv preprint without peer review, and the team has yet to show the kidneys sustain life long term.
Reality
- Evidence50
- Adoption
- Not scored
- Hype gap+30
- Incentives
- Not scored
- Confidence55
UCL preprint maps 2-micrometre channels that carried tau and amyloid toward the mouse brain surface
UCL researchers report a mesh of 2-micrometre channels that carried labelled tau and amyloid beta toward the brain surface in mice, in an unreviewed preprint. They are a candidate exit for the proteins that build up in Alzheimer's, so far untested in a living human brain.
Reality
- Evidence38
- Adoption
- Not scored
- Hype gap+15
- Incentives
- Not scored
- Confidence35
Freedivers' brain networks reorganize over seven months of breath-hold training
Julia Micaux's Paris-Saclay team tracked 17 freedivers through seven months of training and saw connectivity shift across five large-scale brain networks. The authors link the change to preserved memory, but their design can only show that the two go together.
Reality
- Evidence35
- Adoption
- Not scored
- Hype gap+30
- Incentives
- Not scored
- Confidence40
Jesse Poganik's Harvard group reports that donor hearts shifted toward their recipients' biological age in mice and in 11 human transplants. The bioRxiv preprint has not been peer reviewed, so it is enough to question the under-45 donor preference but not to rewrite it.
Perspective Coverage
3 publishers
- Builder
- Builder 45%
- Operator
- Operator 43%
- Investor
- Investor 12%
Reality
- Evidence45
- Adoption
- Not scored
- Hype gap+30
- Incentives
- Not scored
- Confidence55
Preprint puts Jefferson at 99.96 percent likely to have fathered a son with Sally Hemings
A bioRxiv preprint puts Thomas Jefferson near 99.96 percent likely to have fathered at least one of Sally Hemings's sons, using DNA from locks of his preserved hair. A 1998 Y-chromosome test could point only to the Jefferson male line, and the analysis behind the new figure has not been peer-reviewed.
Reality
- Evidence45
- Adoption
- Not scored
- Hype gap+30
- Incentives
- Not scored
- Confidence40
Plunderfish cells cultured for the first time show enlarged lysosomes at near-freezing
A Cambridge and British Antarctic Survey team grew spiny plunderfish cells in the lab, then imaged them alive near 0 degrees Celsius. The preprint reports enlarged lysosomes and more networked mitochondria than in a temperate fish.
Reality
- Evidence42
- Adoption
- Not scored
- Hype gap+30
- Incentives58
- Confidence57
Basecamp raises $140M to push model-designed recombinases toward in vivo cell therapy
The company says the money will train the next generation of its EDEN models. The published evidence so far is one January bioRxiv preprint, co-authored with Nvidia, whose venture arm also put money into the round.
Reality
- Evidence35
- Adoption30
- Hype gap+38
- Incentives80
- Confidence45
Academics get all 9 billion single-base predictions through a browser at no cost, while commercial users wait on a Google Cloud licence whose terms DeepMind has not published, including for its own sister company.
Reality
- Evidence54
- Adoption30
- Hype gap+24
- Incentives78
- Confidence58
Google DeepMind put 111 kilobytes of prediction behind each of 9 billion DNA variants
AlphaGenome Atlas scores every possible single-letter change in the human genome and hands the result to anyone with a browser, which moves the scarce input from computing a prediction to confirming one. Price and drug-developer partnerships go unmentioned in the release.
Reality
- Evidence42
- Adoption20
- Hype gap+28
- Incentives72
- Confidence55
BTI and Cornell pre-compute 800 million mass spectra to give unknown metabolites something to match
Rather than wait for experimental libraries to fill, the Cornell and BTI tool indexes a chemical space roughly a thousand times wider. What a query returns is a candidate structure rather than a confirmed one.
Reality
- Evidence42
- Adoption20
- Hype gap+32
- Incentives62
- Confidence50
Finland sequenced a Saimaa ringed seal, and gave its managers a coordinate system for inbreeding
A team in Finland assembled the species' genome from a living seal caught during a translocation programme, and posted it as a preprint. The population's inbreeding numbers still have to be measured.
Reality
- Evidence55
- Adoption30
- Hype gap+14
- Incentives72
- Confidence52