Topic
Technique that profiles gene expression in individual cells, revealing distinct cell types and states within a tissue or organ.
CellART, an open-source Python tool, segments cells and assigns cell types in one pass on data from four high-resolution spatial transcriptomics platforms. Its MIT licence lets labs that run those steps separately test the swap on their own slides.
Reality
Researchers measured gene activity in over 6 million prefrontal cortex cells from nearly 1,500 donors and published it openly in eight studies. Each sample is a postmortem snapshot, so the map can link cell changes to a disease without showing which came first.
Reality
In Stem Cell Reports, a team led by Benjamin Freedman reports that stem-cell-derived kidney organoids, which contain no immune cells and no blood vessels, shed podocytes in high-glucose media, and that blocking MIF or TNF-alpha protected them. The pattern resembles what patient biopsies show.
Reality
Brown University researchers sequenced more than 12,000 rodent commissural neurons at four developmental stages and found the cell body swapping guidance receptor programs as axons reached the spinal midline. The profiling stops short of manipulating those genes.
Reality
Researchers report in Nature that mouse skull bone marrow holds germinal-centre-like lymphoid structures that respond to CNS antigens and help drive anti-tumour immunity.
Perspective Coverage
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