Topic
Observing living cells over time, where phototoxicity and dye bleaching bound how long acquisition can run.
Tampere University's SF-PULSE recovers quantitative phase images of unstained living cells from a single frame, in a system small enough to sit in an incubator. According to the university, labs can then follow individual cells for hours or days without taking the dish out.
Reality
University of Vienna researchers filmed two Asgard archaea strains crawling on protrusions, a motion previously known only in eukaryotic cells. The team argues that such motility may predate complex cells, a timing claim that so far rests on two lab strains.
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A Cambridge and British Antarctic Survey team grew spiny plunderfish cells in the lab, then imaged them alive near 0 degrees Celsius. The preprint reports enlarged lysosomes and more networked mitochondria than in a temperate fish.
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Alexandra Zidovska's group at NYU built a rotating stage that cancels most of the fluid flow such rigs create, then compared cells under simulated weightlessness, under strong flow, and untouched for 24 hours.
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Binghan Wang and Daniel Kierzkowski report in Current Biology that the fast valves of an Arabidopsis flower pull its slow central band longer than it could grow alone, and that the extra length is where additional ovules fit.
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Held inert inside a live cell until a mild voltage unmasks a reactive ketone, the handle gives chemists a switch for when labelling happens, though the published abstract carries no efficiency or selectivity numbers to judge it by.
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One quenching motif converts constitutively bright fluorophores into turn-on amino acids from the UV to the near-infrared, and a PD-1 peptide built from them flagged avasimibe.
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A framework called REID images living cells with light made inside them, hitting 100 nm detail in 20 ms exposures and 41 hours of continuous mitochondrial footage.
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