Topic
A family of techniques for making targeted changes to DNA in living cells, used in laboratory research and in experimental therapies for genetic disease.
Researchers used a CRISPR-based tool called Y-CUT to delete the Y chromosome from cloned male mouse embryos and got healthy, fertile females. The study is not yet peer-reviewed, and the idea of rescuing small populations depends on species whose XO females can breed.
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LMU researchers report that cloned cattle embryos stripped of interferon tau by CRISPR produced two healthy calves, born on 26 February 2026. Two births refute the decades-old view that the embryonic signal is strictly required, though its effect on pregnancy rates is still unmeasured.
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CTX310, a one-time CRISPR infusion, cut LDL by 52.5% and triglycerides by 47.8% after 12 months at its top dose in a Cleveland Clinic trial. Its 15 patients are enough to show the effect lasts but too few to rule out rare harms or to show it can replace lipid drugs.
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University of Otago researchers built a CRISPR method that disrupts genes across whole phage genomes to tell the essential from the dispensable. Reported in Nature Microbiology, the same transposon can also carry new genes in, so it maps function and engineers it in one step.
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Anthropic's new in-house molecular biology lab says a 21.5 hour agent run turned a 1.9 billion cluster database into 19 reports for humans to read, and one of them described a repeat array nobody had recorded.
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Kevin Davies's Curved Air follows a single point mutation from its 1910 case report to the two gene therapies approved in December 2023, and Davies calls the disease underfunded and forgotten by much of medicine and pharma.
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Two Science papers name the protein VIPR and show it silencing a reporter gene and blocking phage in E. coli, guided by an RNA that reads two DNA letters and skips the third, a targeting rule anyone borrowing it will have to design around.
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Researchers screened dozens of candidate morphogenic genes crop by crop, then switched the winners on alongside the edit itself, and wild strawberry reached a fully regenerated edited plant more than a month faster.
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Two children have died in separate Chinese gene-editing trials, one death announced by the company running it and the other uncovered by journalists. China's fast-track trial route requires no drug-regulator supervision.
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