Washington University researchers report that a CXCR3-blocking antibody halved brain T cells and spared 40% more memory-region tissue in tauopathy mice. Tau levels never fell, evidence the immune reaction to tau does much of the killing.
Perspective Coverage
3 publishers
- Builder
- Builder 53%
- Operator
- Operator 25%
- Investor
- Investor 22%
Reality
- Evidence55
- Adoption
- Not scored
- Hype gap+30
- Incentives40
- Confidence60
Human stem cell grafts repaired four things at once in stroke-injured mice
A University of Zurich team transplanted human neural stem cells a week after inducing strokes in mice, and reported new neurons, new blood vessels, a tighter blood-brain barrier and restored walking in the same animals.
Reality
- Evidence32
- Adoption
- Not scored
- Hype gap+28
- Incentives72
- Confidence46
Single-cell maps date a microglial handover in the hippocampus to ages 50 through 75
A Science paper reads gene regulation cell by cell in the human hippocampus and finds embryonic microglia giving way to cells with blood-like inflammatory signatures across a 25-year band of adult life.
Reality
- Evidence58
- Adoption
- Not scored
- Hype gap+22
- Incentives62
- Confidence45
Ultrasound brain delivery peaks mid-range across a 20-fold span of particle sizes in mice
A University of Virginia group turned an MRI scanner into a nanoparticle counter and found that delivery through an ultrasound-opened blood-brain barrier rose to 15 nm, held at 23 nm, then fell away at 45 nm.
Reality
- Evidence54
- Adoption18
- Hype gap+15
- Incentives55
- Confidence57
A gut metabolite that weakens the blood-brain barrier gives the Alzheimer's story a target
Researchers report in Nature Communications that imidazole propionate, made by gut bacteria from histidine, weakens the blood-brain barrier and worsens amyloid and tau. The human data is associative.
Reality
- Evidence58
- Adoption
- Not scored
- Hype gap+12
- Incentives52
- Confidence55