Peer-reviewed scientific journal published by Cell Press covering neuroscience research, from molecular mechanisms to brain disorders and behavior.
Researchers at The Ottawa Hospital reversed autism-linked behaviours in 16p11.2 mice by restoring blood flow in brain vessels that held half the normal ATP. The drug that did it is already approved for people in Japan and South Korea, though for dry eye, not autism.
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Weill Cornell-led researchers found 18% of under-65 patients had cognitive impairment within two years of neck lymph node removal, versus 4-6% expected. Because the comparison is with population rates, the finding makes a firmer case for cognitive follow-up than for cutting less.
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Washington University researchers report that a CXCR3-blocking antibody halved brain T cells and spared 40% more memory-region tissue in tauopathy mice. Tau levels never fell, evidence the immune reaction to tau does much of the killing.
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Salk researchers recorded and then manipulated the amygdalostriatal transition zone in freely moving mice, and report in Neuron that dopamine-expressing neurons there are needed to mount a fear response.
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Carriers of the CAG-CCG loss-of-interruption variant start having motor symptoms up to 12.5 years earlier than other Huntington patients. A UBC-led team measured the long expansions in their isolated striatal neurons, and saw no matching signal in blood.
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Researchers at DIfE and Charite paced breathing at a two-to-eight inhale-exhale ratio and saw bolder bets alongside stronger reward-region activity. The release names the direction of the effect but not its size.
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WashU and Princeton report that early-life stress raises SETD7 in mouse dopamine neurons, leaving stress genes easier to switch on. Blocking the mark it deposits prevented the adult phenotype.
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