Peer-reviewed journal from Springer Nature covering clinical and translational medical research, including new therapies and diagnostics.
Casey Harrell, who has ALS, has communicated nearly 2 million words through a brain implant, his team reported in Nature Medicine. The record is one patient's, and the researchers Science News quotes expect others to follow.
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Weizmann Institute researchers analyzed more than 300 million lab tests from over a million women and report step-like shifts at menopause. In the Nature Medicine paper the largest changes sit in bone metabolism, liver tests and lipid handling.
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Connor Dalby, who had tried 12 or 13 anti-seizure drugs, took unassisted steps about four months after starting a drug built for his SCN2A mutation. His case, now in Nature Medicine, is a single patient, so how often made-to-order drugs like his work is still unknown.
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Toronto and UCSF researchers report that older women with higher levels of 16 menopause-linked molecules were 15 percent likelier to develop Alzheimer's. The authors see menopause as a window for early-warning testing, though the evidence so far is a correlation.
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Researchers writing in Nature Medicine pooled data on over 6 million people in 118 countries and found women report more pain than men at all 11 body sites. The authors say the steep climb in pain before 55 argues for prevention during working age.
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Nature's editors want AI medical devices tested in real clinics, noting that just 19 of some 4,600 clinical AI papers were prospective randomized trials. Until the FDA decides, hospitals need to check whether a vendor's accuracy figure came from real patients or from a simulation.
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The Berlin phase 1 trial was built to measure cytokine release syndrome rather than remission, and its six-patient denominator carries no comparator, so the ten-patient second phase against an approved B-cell drug is the one that settles anything.
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UCSF researchers tied 16 blood proteins that shift with menopausal hormones to a 15% higher Alzheimer's risk in nearly 12,000 older women. Those women were in their 60s and 70s, so a menopause screening test would need a study that follows the same women from midlife.
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In the Penda Health trial, LLM support improved documentation and treatment plans while 14-day failure ran 2.2% against 2%, and the FDA's discussion paper on how to evaluate such tools is still only collecting comments.
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A City of Hope team reports catching stage 1 and 2 pancreatic cancer from a three-marker blood score. The trial does not settle what a positive means in the high-risk groups a screening programme would enrol first.
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A Nature Medicine study from Washington University reports that more recent generations look biologically older than earlier ones did at the same age, and that a larger gap goes with higher risk of early-onset cancer.
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The Class IIb certification only covers screening cases the AI calls clearly normal, and the trial behind it measured AI-assisted double reading, which makes the monitoring layer the part a programme is really buying.
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Twenty-six risk regions, about half of them near genes for nerve cell growth and pain sensitivity, give the condition the biological footing that decades of clinical dismissal lacked, though none of them can diagnose a patient.
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For anyone with staff, suppliers or travel in the region, the useful planning number is the growth rate and the spread of health zones rather than the confirmed case total, and both point to a disruption measured in quarters.
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A natural experiment at the October 2017 vaccine changeover gives the cardiovascular claim a cleaner comparison group. It also means nobody has yet measured Shingrix against no vaccine.
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The first human evidence for the neurogenesis hypothesis arrives with a hedge from the lead author and no described way to measure the marker in a living patient.
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Eight countries have already logged 33,000 heat-linked deaths this summer. The EU's promised heat and cooling plan, due in April, still has not appeared.
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Whole-genome sequencing of parasites from hundreds of Ugandan patients links five variants to reduced susceptibility to artemisinin, lumefantrine and mefloquine, according to Nature Medicine.
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UCL, Oxford and the UK AI Security Institute rated 810 simulated therapy conversations across nine models. Concerning replies were rare at the opening and grew more likely as sessions went on.
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